Saturday, 5 March 2011
HIV Breakthrough: Protein That Fights Immunodeficiency Identified: HIV Breakthrough: Protein That Fights Immunodefici...
HIV Breakthrough: Protein That Fights Immunodeficiency Identified: HIV Breakthrough: Protein That Fights Immunodefici...: "HIV Breakthrough: Protein That Fights Immunodeficiency Identified — A Canada-U.S. research team has solved a major genetic myster..."
HIV Breakthrough: Protein That Fights Immunodeficiency Identified
HIV Breakthrough: Protein That Fights Immunodeficiency Identified
— A Canada-U.S. research team has solved a major genetic mystery: How a protein in some people's DNA guards them against killer immune diseases such as HIV. In an advance online edition of Nature Medicine, the scientists explain how the protein, FOX03a, shields against viral attacks and how the discovery will help in the development of a HIV vaccine.
- "HIV infection is characterised by the slow demise of T-cells, in particular central memory cells, which can mediate lifelong protection against viruses," said lead researcher Rafick-Pierre Sékaly, a Université de Montréal professor and a researcher at the Centre Hospitalier de l'Université de Montréal and the French Institut national de la santé et de la recherche médicale (Inserm).
- "Our group has found how the key protein, FOX03a, is vital to the survival of central memory cells that are defective in HIV-infected individuals even if they are treated," added Dr. Sékaly, who produced his study with CHUM and Inserm colleagues including Elias El Haddad and Julien van Grevenynghe. Collaborators also included Jean-Pierre Routy, a McGill University Health Centre researcher and professor at McGill University and Robert S. Balderas, Vice-President of Research and Development at BD Biosciences of San Diego, CA.
- Public support for the research came through Genome Canada and Génome Québec, among others, while private contributions came via a segment of BD (Becton, Dickinson and Company). "Public-private collaborations such as this play an important role in advancing medical research," Robert S. Balderas. "BD Biosciences was pleased to provide powerful research instruments, reagents and technical expertise to support this breakthrough research."
- The breakthrough emerged by studying three groups of men: One HIV-negative sample, a second HIV-positive group whose infection was successfully controlled through tritherapy and a third group whose HIV did not show any symptoms. Called elite controllers, this third group fended off infection without treatment because their immune system, which would normally be attacked by HIV, maintained its resilient immune memory through the regulation of the FOX03a protein.
- "Given their perfect resistance to HIV infection, elite controllers represent the ideal study group to examine how proteins are responsible for the maintenance of an immune system with good anti-viral memory," said Dr. Haddad. "This is the first study to examine, in people rather than animals, what shields the body's immune system from infection and to pinpoint the fundamental role of FOX03a in defending the body."
- Beyond HIV treatment, Dr. Sékaly said his team's discovery offers promise for other immune diseases. "The discovery of FOX03a will enable scientists to develop appropriate therapies for other viral diseases that weaken the immune system," he said, citing cancer, rheumatoid arthritis, hepatitis C, as well as organ or bone marrow transplant rejection.
- Paul L'Archevêque, president and CEO of Génome Québec, lauded Dr. Sékaly's team for their breakthrough and the people who volunteered for the study. "This discovery, the first such study in humans, is a major step forward in the understanding of how our immune system responds to life-threatening infections such as HIV. This advance stems directly from research co-financed by Génome Québec, which demonstrates the impact that genomic research can have in improving healthcare."
- This research was made possible by public and private institutions across Canada, the United States and France: the Université de Montréal, CHUM, Inserm, MUHC, Genome Canada, Génome Québec, Fonds de la recherche en santé du Québec, Canadian Institutes of Health Research, National Institutes of Health and BD Biosciences.
ULTIMATE NUTRITION-the future of sport nutrition
An athlete wanting to rip up and show muscle definition, a girl looking for a perfect hour-glass figure, and an overweight person trying to shed kilos of weight…What do they have in common?
They all want FAT LOSS.
Fat loss is not just weight loss. It is a scientific approach that targets burning off the excess body fat while preserving the lean muscle tissue.
A balanced fitness regime of regular intense exercise and a sports nutrition diet helps the body to develop its natural muscularity and strength. Stripping the body of excess fat reveals a muscular toned body that will give the ideal shape to both a male and female body.
THE FAT LOSS KEY
The key to fat loss is to rev up the body's calorie-burning engine i.e. its basal metabolic rate (BMR). The BMR or basal metabolic rate is the speed at which the body burns calories 24 hours a day even at rest for all its internal functioning i.e. metabolism.
Accelerate your BMR and you speed up fat loss. 24x7.
3 Simple Steps To Accelerate Fat Loss:
Rev up the BMR engine: Adequate Protein Adequate protein of first-class quality is the raw material for increasing muscle repair and BMR after weight training. If protein in the diet is not enough for muscle repair, weight training fails to lead to fat loss.
Often misunderstood to be for weight gain, protein is actually the lowest-calorie nutrient as most of its calories are used up during its own digestion and for the muscle repair.
Shift to fat-burning gear: Calorie-burning 'thermogenic' foods Only cutting out fattening foods from the diet is not enough. We need to shift our body into a high-speed fat-burning gear by adding 'high-thermogenic' foods, i.e. foods that make you burn fat.
The effort of their digestion, absorption and metabolism is so high that the body's BMR and calorie-burn increases simply by eating these 'high-thermogenic' foods. Eaten in every meal, every 3-4 hours throughout the day, they keep the body in a continuous fat-burning state.
Fibrous vegetables and salads, essential fatty acids and protein are foods with highest thermogenic value.
AN IDEAL FAT LOSS DIET
Guidelines for the Ideal Fat Loss diet:
1. Five-Meal Eating Pattern:
a) Small, frequent meals every 3-4 hours
b) No skipping of meals
Skipping meals or long gaps in meals signals the body into starvation mode, i.e. it slows down BMR to conserve energy and stores more calories as fat.
2. Drop The Carbs, Up The Fibre:
a) Increase high-fibre green vegetables and salads.
1. Five-Meal Eating Pattern:
a) Small, frequent meals every 3-4 hours
b) No skipping of meals
Skipping meals or long gaps in meals signals the body into starvation mode, i.e. it slows down BMR to conserve energy and stores more calories as fat.
2. Drop The Carbs, Up The Fibre:
a) Increase high-fibre green vegetables and salads.
Green vegetables and salads are a must in the evening and night to stimulate the low BMR.
b) Include fibrous fruits such as apple, orange, papaya, and guava.
In the morning, the fruit sugar is used well. But a fruit in the evening or after dinner will go into fat.
c) Limit whole cereals such as wheat and oats for sustained energy release
d) Cut out totally from the diet:
3. Adequate Protein 24x7
a) Include first-class protein sources
b) Distribute equally in small quantities in every meal
4. Optimum Hydration
a) Intake an average of 4-5 litres of water and fluids distributed throughout the day.
Note: Individual water requirement depends on various factors such as the lean body mass and workout intensity.
5. Fat-Burning 'Essential' Fats
a) Include good quality fats such as Omega-3 fats and MUFA (mono-unsaturated fatty acids)
b) Take fish or flaxseed oil capsules with 2-3 meals daily such as breakfast, lunch and dinner
6. Anti-Aging Antioxidants
a) Take antioxidants such as vitamin C 1gm and vitamin E 400IU immediately after workout
ULTIMATE NUTRITION'S FAT LOSS STACK
An effective stack of fat loss supplements is:
PRODUCT 1: Whey protein to trigger muscle repair and fat-burning after workout (afterburn)
OR
Use: Pre-workout (in milk), post-workout (in water) and with any low-protein meal.
PRODUCT 2: Low-carb MRP (meal replacement powder) to increase fat-burning in evening and night, when body's metabolism slows down
Use: Once or twice a day; in evening, dinner or bedtime meals; preferably with salad or green vegetables
PRODUCT 3: Essential fatty acids (omega-3) to give a 'thermogenic' effect that boosts metabolism and fat-burning
OR
Use: 3 capsules a day; one each with breakfast, lunch and dinner.
PRODUCT 4: Fat burner to increase lipolysis (fat breakdown) by acting on the central nervous system and stimulating metabolism. For best results, add a fat burner in the middle or end of a strictly followed fat loss program.
OR
Use: 1-2 capsules twice a day before meals; pre-workout and 6-8hours apart (not after 6pm)
WARNING: Fat burners cannot be used by individuals with existing health problems or at risk of the same. Please read the label carefully before use.
SAMPLE SUPPLEMENTATION SCHEDULE*
I. FOR MORNING WORKOUT
| Empty stomach: 1-2 caps Ultra Ripped/ Perfect Diet |
| Meal 1: Breakfast: 2-3 tbsp Oats in skim milk + 1 scoop Prostar whey/ Isosensation93 in skim milk |
| Morning Workout |
| Meal 2: Post-workout After high-intensity weight training: 3-4 tbsp glucose in 300-400ml water. After 15-20min: 1 scoopProstar whey/ Isosensation93 in water After cardio/ on rest days: 1 Apple/ Pear + 1 scoop Prostar whey/ Isosensation93 in skim milk |
| Meal 3: Lunch: 1 wheat chapatti + 1 bowl green vegetables + 6 egg whites or 1 scoop Prostar whey/ Isosensation93 in skim milk + 1 cap Omega-3/ Flaxseed Oil |
| 30min before meal (not after 6pm): 1-2 caps Ultra Ripped/ Perfect Diet |
| Meal 4: Evening: 2 scoops Magic Milk in water + 1 bowl salad + 1 cap Omega-3/ Flaxseed Oil |
| Meal 5: Dinner: 1 bowl green vegetables + 1 bowl salad + 1 bowl Skimmed paneer or 1 breast pc Chicken or 100gm Fish or 2 scoops Magic Milk in water + 1 cap Omega-3/ Flaxseed Oil |
II. FOR EVENING WORKOUT
| Empty stomach: 1-2 caps Ultra Ripped/ Perfect Diet |
| Meal 1: Breakfast: 2-3 tbsp Oats in skim milk + 1 scoop Prostar whey/ Isosensation93 in water + 1 cap Omega-3/ Flaxseed Oil |
| Meal 2: Mid-morning: 1 Apple/ Pear + 1 scoop Prostar whey/ Isosensation93 in water |
| Meal 3: Lunch: 1 wheat chapatti + 1 bowl green vegetables + 6 egg whites or 1 scoop Prostar whey/ Isosensation93 in skim milk + 1 cap Omega-3/ Flaxseed Oil |
| 30min before meal (not after 6pm): 1-2 caps Ultra Ripped/ Perfect Diet |
| Meal 4: Pre-workout: 2 scoops Magic Milk in water + 1 bowl salad |
| Evening Workout |
| Post-workout meal (Only after high-intensity weight training): 3-4 tbsp glucose in 300-400ml water. After 15-20min: 1 scoop Prostar whey/ Isosensation93 in water |
| Meal 5: Dinner: 1 bowl green vegetables + 1 bowl salad + 1 bowl Skimmed paneer or 1 breast pc Chicken or 100gm Fish or 2 scoops Magic Milk in water + 1 cap Omega-3/ Flaxseed Oil |
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